As with every journey into purgatory, the journey in Painkiller: Resurrection starts with death and pain. William 'Wild Bill' Sherman, an ex CIA Agent and specialist for dangerous missions in the Black Ops Special Unit has a big problem: during his last job, he has managed to not only kill the head of an illegal drug operation and a slew of innocent civilians, but himself in a fatal mistake. Trapped in a hostile place between heaven and hell, his soul flickers between the millions of faceless infidels and good and evil forces start to use Wild Bill for their own needs. But, it turns out that nothing is as it seemed at the beginning… solve the mystery and give the equilibrium between heaven and hell a little flip!